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A human short-chain dehydrogenase/reductase gene: structure, chromosomal localization, tissue expression and
Silvia Pellegrini1, Stefano Censini, Silvia Guidotti
1Department of Experimental Pathology and Medical Biotechnology, University of Pisa, Via S. Zeno 37, I-56127 Pisa, Italy.
Biochimica Et Biophysica Acta
|May 9, 2002
Abstract:
We have previously described the cloning of Hep27, a short-chain dehydrogenase/reductase, which is synthesized in human hepatoblastoma HepG2 cells following growth arrest induced by butyrate treatment. The present report describes the cloning, the structure and the physical and cytogenetic mapping of the gene coding for Hep27. We also show that Hep27 is synthesized in a limited number of human normal tissues and that it is localized in the nuclei and cytoplasm of HepG2 cells.