Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Large-scale protein annotation through gene ontology.

Hanqing Xie1, Alon Wasserman, Zurit Levine

  • 1Compugen Inc., Jamesburg, New Jersey 08831, USA. han@cgen.com

Genome Research
|May 9, 2002
PubMed
Summary

GO Engine annotates human proteins using genomic data and Gene Ontology (GO) for biological insights. This platform enhances protein annotation accuracy and aids in discovering novel functional information.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

When Your Heart Goes Out to the Child: Reflections on Therapist-Initiated Termination of Treatment in Child and Youth Therapy Groups.

International journal of group psychotherapy·2025
Same author

Machine-Learning-Aided Engineering Hemoglobin as Carbene Transferase for Catalyzing Enantioselective Olefin Cyclopropanation.

JACS Au·2024
Same author

Directed evolution of <i>Escherichia coli</i> surface-displayed <i>Vitreoscilla</i> hemoglobin as an artificial metalloenzyme for the synthesis of 5-imino-1,2,4-thiadiazoles.

Chemical science·2024
Same author

PVRIG is Expressed on Stem-Like T Cells in Dendritic Cell-Rich Niches in Tumors and Its Blockade May Induce Immune Infiltration in Non-Inflamed Tumors.

Cancer immunology research·2024
Same author

Application of Vitreoscilla Hemoglobin as a Green and Efficient Biocatalyst for the Synthesis of Benzoxazoles in Water.

Chembiochem : a European journal of chemical biology·2023
Same author

Engineering of Dual-Function <i>Vitreoscilla</i> Hemoglobin: A One-Pot Strategy for the Synthesis of Unnatural α-Amino Acids.

Organic letters·2023

Area of Science:

  • Genomics
  • Computational Biology
  • Bioinformatics

Background:

  • Advancements in genomic sequencing and computational biology enable novel approaches to understanding biological systems.
  • The Gene Ontology (GO) provides a hierarchical framework for describing gene and protein functions.
  • Investigating biological systems through the structured lens of GO offers unique analytical perspectives.

Discussion:

  • GO Engine is a novel computational platform designed for Gene Ontology (GO) annotation and analysis of human proteins.
  • Protein annotation integrates sequence homology, protein domain analysis, and text mining for enhanced accuracy.
  • A multiparameter cellular localization prediction tool is employed to refine annotations and identify novel functional assignments.

Key Insights:

Related Experiment Videos

  • The majority of human proteins from GenBank and the NR database have been successfully annotated with GO terms across all three GO categories.
  • GO Engine significantly improves the accuracy and scope of protein annotations.
  • The platform facilitates the prediction of new protein functions and cellular localizations.

    • Outlook:

    • Publicly accessible annotations for GenBank and SWISS-PROT proteins are available via the GO Consortium website.
    • Future work may involve expanding GO Engine to other proteomes and integrating additional data types.
    • This work lays the foundation for more comprehensive functional genomics studies.