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Updated: Oct 1, 2026

Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs
Published on: April 17, 2021
[Myocardial revascularization at the acute phase of myocardial infarction in the octogenarian]
J Horvilleur1, H Benamer, P Aubry
1Service de cardiologie de l'hôpital Bichat, 46, rue Henri Huchard, 75018 Paris.
Insights
Primary angioplasty is a viable reperfusion strategy for elderly patients over 80 experiencing acute myocardial infarction (AMI), demonstrating improved outcomes and reduced mortality rates in this high-risk group.
Area of Science:
- Cardiology
- Geriatric Medicine
- Interventional Cardiology
Context:
- Elderly patients (over 80) face high risks with acute myocardial infarction (AMI).
- Myocardial reperfusion significantly improves prognosis in this demographic.
- Traditional thrombolytic therapy has limitations in octogenarians.
Purpose:
- To evaluate the efficacy and safety of coronary angioplasty as a reperfusion strategy in patients over 80 years old with AMI.
- To assess in-hospital mortality rates and complication rates associated with angioplasty in this elderly population.
Summary:
- A prospective registry included 92 patients over 80 with AMI within 6 hours of symptom onset.
- Coronary angioplasty was performed in 63% of patients with an 86% success rate.
- In-hospital mortality was 26%, significantly lower (20%) in the absence of cardiogenic shock. A trend towards decreased mortality was observed over time.
Impact:
- Primary angioplasty is feasible and effective for reperfusion in octogenarian AMI patients, with manageable complication rates.
- This study supports the use of angioplasty in elderly patients, encouraging further evaluation of newer techniques like stents and GpIIb/IIIa inhibitors in this population.
Abstract:
Elderly patients are at high risk of complications in acute myocardial infarction (AMI). In this population, myocardial reperfusion at the acute phase improves the prognostic. The mortality rate is above 50% in the absence of reperfusion strategy, and decreases at less than 20% in case of such treatment. The thrombolytic use is limited in those patients, coronary angioplasty is taking an important place in this reperfusion therapy, but is not well evaluated in patients older than 80 years. Prospective registry of patients older than 80 years admitted in Hôpital Bichat for acute myocardial infarction within the first 6 hours (n = 92), between 1990 january to 1999 december. Eight patients (10%) received a thrombolytic therapy. Coronary angiogram was achieved in eighty patients (87%). In 58 (63%) patients a coronary angioplasty was performed. The success rate of the coronary angioplasty was 86%. In-hospital mortality rate was 26% (death in 24 patients), 20% in the absence of cardiogenic shock and 62% when this complication was noted. Two patients (2%) were treated by emergent coronary artery bypass surgery. The results comparison between the periods of 1990 to 95 and 1955 to 99 showed, a real trend of decrease mortality rate (28 to 13% in the absence of cardiogenic shock, p = 0.10), an increase of the proportion of patients treated by angioplasty. These results are more and more encouraging. Coronary reperfusion by primary angioplasty in possible in patients older than 80 years with a low rate of complications. Technical progress such as stents and GpIIb/IIIa inhibitors must be evaluated in this population.
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