Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Emerging Chagas disease in Amazonian Brazil.

José Rodrigues Coura1, Angela C V Junqueira, Octavio Fernandes

  • 1Dept of Tropical Medicine, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, Brazil. coura@ioc.fiocruz.br

Trends in Parasitology
|May 10, 2002
PubMed
Summary

Chagas disease is increasing in the Amazon Basin due to Trypanosoma cruzi infections in mammals and bugs. Genetic diversity of T. cruzi strains poses challenges for disease control efforts.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

'Reservoir dogs': The emerging zoonotic risk associated with European dog imports to the UK.

The Veterinary record·2026
Same author

Human helminth infections above latitude 60°N: reports published 2001-2024.

Parasitology·2025
Same author

Diversity of Chagas disease diagnostic antigens: Successes and limitations.

PLoS neglected tropical diseases·2024
Same author

A Multi-Epitope Protein for High-Performance Serodiagnosis of Chronic Chagas Disease in ELISA and Lateral Flow Platforms.

International journal of molecular sciences·2024
Same author

Chagas Disease Diagnosis with <i>Trypanosoma cruzi</i>-Exclusive Epitopes in GFP.

Vaccines·2024
Same author

Comparative genomics of Leishmania donovani progeny from genetic crosses in two sand fly species and impact on the diversity of diagnostic and vaccine candidates.

PLoS neglected tropical diseases·2024

Area of Science:

  • Tropical Medicine
  • Infectious Diseases
  • Parasitology

Background:

  • Trypanosoma cruzi infection is endemic in the Amazon Basin, affecting wild mammals and triatomine bugs.
  • Increasing human cases of Chagas disease signal a potential public health emergence in the region.

Purpose of the Study:

  • To review the current status of Chagas disease in Amazonian Brazil.
  • To identify reservoirs, vectors, and the genetic diversity of T. cruzi.
  • To assess the risk of domestic transmission and inform control strategies.

Main Methods:

  • Literature review of Chagas disease status in Amazonian Brazil.
  • Analysis of known reservoirs and vectors of T. cruzi.
  • Examination of T. cruzi genetic diversity, including subspecific groups.

Related Experiment Videos

Main Results:

  • At least three subspecific groups of T. cruzi (T. cruziZ1, T. cruziZ3, T. cruziZ3/Z1 ASAT) are present in the Amazon Basin.
  • T. cruzi exhibits an extant capacity for genetic exchange.
  • A significant increase in human Chagas disease cases has been observed.

Conclusions:

  • Chagas disease poses a growing public health concern in Amazonian Brazil.
  • The genetic diversity of T. cruzi complicates disease control.
  • There is a notable risk of domestic endemicity, requiring focused control measures.