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Related Experiment Videos

New animal model for atherosclerosis research.

C E Day, W W Stafford

    Advances in Experimental Medicine and Biology
    |January 1, 1975
    PubMed
    Summary

    Japanese quail showed variable atherosclerosis development, hindering their use as a model. Selective breeding created a susceptible line, establishing a new animal model for atherosclerosis research.

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    Area of Science:

    • Cardiovascular Research
    • Animal Models
    • Pharmacology

    Background:

    • Japanese quail possess traits suitable for screening anti-atherosclerosis compounds.
    • However, their natural development of atherosclerosis is highly variable, limiting their utility.
    • A consistent animal model is needed for effective drug discovery.

    Purpose of the Study:

    • To evaluate Japanese quail as a model for anti-atherosclerosis compound discovery.
    • To develop a more uniform and practical animal model for atherosclerosis research.

    Main Methods:

    • Investigated Japanese quail for their suitability as a screening model.
    • Conducted selective breeding to establish a line susceptible to experimental atherosclerosis.
    • Developed the susceptible to experimental atherosclerosis (SEA) Japanese quail line.

    Main Results:

    • Japanese quail exhibited variable atherosclerosis development, deeming them impractical.
    • Selective breeding successfully produced a line with uniform atherosclerosis susceptibility.
    • The SEA Japanese quail line was established as a novel animal model.

    Conclusions:

    • The SEA Japanese quail represents a significant advancement in atherosclerosis research models.
    • This new model offers improved consistency for evaluating anti-atherosclerosis compounds.
    • The SEA quail model is poised to enhance the discovery and development of new therapies.

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