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Related Experiment Videos

Visual field constriction and electrophysiological changes associated with vigabatrin.

Dorothea Besch1, Anne Kurtenbach, Eckart Apfelstedt-Sylla

  • 1Department of Neuro-Ophthalmology and Pathophysiology of Vision, University Eye Hospital, Tübingen, Germany. dorothea.besch@uni-tuebingen.de

Documenta Ophthalmologica. Advances in Ophthalmology
|May 10, 2002
PubMed
Summary

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Vigabatrin (VGB) therapy in epilepsy patients can cause visual field constriction, even without reported symptoms. Electrophysiological tests reveal inner retinal layer dysfunction, suggesting GABA-ergic transmission issues.

Area of Science:

  • Neuroscience
  • Ophthalmology
  • Pharmacology

Background:

  • Vigabatrin (VGB) is an anti-epileptic drug that inhibits GABA aminotransferase.
  • Visual field changes are a known potential side effect of VGB therapy.
  • This study investigates subclinical visual system alterations in patients on VGB.

Purpose of the Study:

  • To investigate functional, morphological, and electrophysiological changes in epileptic patients undergoing anti-epileptic therapy with vigabatrin (VGB).
  • To assess visual field defects and retinal function in patients treated with VGB, even in the absence of subjective visual complaints.

Main Methods:

  • 20 epileptic patients (25-66 years) on VGB therapy were evaluated.
  • Psychophysical tests included color vision, dark adaptation, and visual fields (Goldmann, Tuebingen Automated Perimetry).

Related Experiment Videos

  • Electrophysiological assessments comprised Ganzfeld ERG, EOG, and VERIS multifocal ERG with oscillatory potentials.

    • Main Results:

    • 18 out of 20 patients exhibited visual field constriction.
    • All patients with visual field defects showed altered electroretinogram (ERG) oscillatory potentials.
    • Some patients displayed delayed cone single flash responses, reduced mfERG amplitude, and reduced Arden ratios.

    Conclusions:

    • Vigabatrin (VGB) therapy affects the inner retinal layers.
    • Abnormalities in oscillatory potentials correlate with visual field defects, suggesting GABA-ergic retinal cell transmission dysfunction.