Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Vigabatrin and retinal changes.

Hanne Jensen1, Ole Sjö, Peter Uldall

  • 1Department of Pediatric Ophthalmology and Handicap, Center for Handicapped, Glostrup, Denmark.

Documenta Ophthalmologica. Advances in Ophthalmology
|May 10, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluating the Role of Surgical Telementoring in the Acquisition of Surgical Skills in Laparoscopic Cholecystectomy: Protocol for a Pilot Randomized Controlled Trial.

JMIR research protocols·2026
Same author

Visual profiling and vision screening of preschool children in Greenland.

International journal of circumpolar health·2025
Same author

Vision screening of school children in greenland 2017-2022: coverage and low vision prevalence.

International journal of circumpolar health·2024
Same author

Vision screening and refraction of Greenlandic schoolchildren.

Acta ophthalmologica·2024
Same author

Surgical telementoring as teaching tool in the operating room: trans-Nordic IDEAL stage 2a telementored series of a robotic ventral mesh rectopexy learning curve.

The British journal of surgery·2024
Same author

Temporal changes in incidence, prevalence and causes of childhood visual impairment - Learnings from 45 years with the National Danish Registry of Children with Visual Impairment.

Acta ophthalmologica·2024

Vigabatrin treatment in epilepsy patients can cause visual field constriction (VFC). Electroretinography (ERG) changes were observed in patients with VFC, particularly with higher drug doses.

Area of Science:

  • Neuroscience
  • Ophthalmology

Background:

  • Vigabatrin is an effective antiepileptic drug.
  • Visual field constriction (VFC) is a known severe side effect.

Purpose of the Study:

  • To investigate the relationship between vigabatrin-induced VFC and electroretinography (ERG) changes.
  • To assess if ERG abnormalities can predict or correlate with VFC in patients treated with vigabatrin.

Main Methods:

  • Twenty epilepsy patients were divided into two groups: one treated with vigabatrin, the other a control.
  • Ophthalmic examinations included Goldmann perimetry for VFC and ERG to assess retinal function.

Main Results:

  • 30% of vigabatrin-treated patients developed VFC, compared to none in the control group.

Related Experiment Videos

  • ERG abnormalities, including changes in scotopic, photopic potentials, and oscillatory potentials (OPs), were more frequent in the vigabatrin group.
  • All patients with VFC showed ERG changes; severe ERG abnormalities correlated with high vigabatrin doses (4-6 mg daily).

    • Conclusions:

    • Vigabatrin treatment is associated with a significant incidence of VFC and ERG changes.
    • While abnormal ERG is not synonymous with VFC, it indicates retinal dysfunction and is more prevalent in patients with VFC.
    • Individual sensitivity to vigabatrin may play a role, with high doses linked to severe ERG alterations.