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Related Experiment Videos

Controlled exposures to volatile organic compounds in sensitive groups.

N Fiedler1, H M Kipen

  • 1UMDNJ-Robert Wood Johnson Medical School, Environmental and Occupational Health Sciences Institute, Piscataway, New Jersey 08854, USA. nfiedler@eohsi.rutgers.edu

Annals of the New York Academy of Sciences
|May 10, 2002
PubMed
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Chemical sensitivities can cause multi-organ symptoms. Controlled studies show sensitive individuals react to specific chemical exposures, but not always with physiological arousal, highlighting the importance of subject characteristics.

Area of Science:

  • Environmental Health
  • Toxicology
  • Neuroscience

Background:

  • Chemical sensitivities involve diverse symptoms from low-level exposures.
  • Studies examine multiple chemical sensitivity (MCS), Gulf War veterans (CFS/CS), and MTBE-sensitive individuals.
  • Healthy controls are used for comparison in all studies.

Purpose of the Study:

  • To review controlled exposure studies on chemical sensitivities.
  • To investigate responses to odorants and volatile organic compounds.
  • To explore the role of physiological arousal in chemical sensitivity.

Main Methods:

  • Controlled olfactory and chemical mixture exposure studies.
  • Comparison of sensitive subgroups (MCS, CFS/CS, MTBE-sensitive) with healthy controls.

Related Experiment Videos

  • Assessment of odor thresholds, symptom reporting, and autonomic arousal (heart rate, respiration, end-tidal CO2).

    • Main Results:

    • No lower odor thresholds found in MCS subjects, but dose-response symptoms observed for phenyl ethyl alcohol.
    • MTBE-sensitive subjects showed increased symptoms at higher MTBE concentrations.
    • Gulf War veterans (CFS/CS) exhibited reduced end-tidal CO2 with diesel fumes, unlike MTBE-sensitive subjects.

    Conclusions:

    • Chemically sensitive individuals can show significant responses to controlled exposures.
    • Symptoms do not always correlate with physiological arousal changes.
    • Individual subject characteristics are crucial determinants of outcomes in chemical sensitivity studies.