Stereospecific synthesis of cryptophycin 1
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1Department of Chemistry, 2545 The Mall, University of Hawaii, Honolulu 96822, USA.
Abstract:
[reaction: see text] A brief stereospecific synthesis of cryptophycin 1 is described in which (R)-mandelic acid serves as the sole source of asymmetry for unit A. The key step is a hetero-Diels-Alder cycloaddition.
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