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A copper-free Sonogashira coupling reaction in ionic liquids and its application to a microflow system for efficient
Takahide Fukuyama1, Masutaka Shinmen, Satoshi Nishitani
1Department of Chemistry, Faculty of Arts and Sciences, Osaka Prefecture University, Sakai 599-8531, Japan.
Organic Letters
|May 10, 2002
Abstract:
[reaction: see text] The PdCl2(PPh3)2-catalyzed Sonogashira coupling reaction, in good to high yields, was performed in an ionic liquid ([BMIm][PF6]) in the absence of a copper salt. The use of an ionic liquid allows for the facile separation and recycling of the catalyst. The application of the above reaction in a microflow system in conjunction with an IMM micromixer was also successful.