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Synthesis of alkaloid 223A and a structural revision
Naoki Toyooka1, Ayako Fukutome, Hideo Nemoto
1Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Sugitani 2630, 930-0194, Japan. toyooka@ms.toyama-mpu.ac.jp
Organic Letters
|May 10, 2002
Abstract:
[structure: see text] Synthesis of alkaloid 223A has been achieved by sequential use of our original conjugate addition reaction to enaminoesters as the key step. The proposed structure for natural 223A (A, absolute configuration unknown) was revised to B, and the relative stereostructure was determined to be 5R*,6R*,8R*,9S* by the present synthesis.