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Does Hermansky-Pudlak syndrome predispose to systemic lupus erythematosus?
H Mitsui1, M Komine, T Watanabe
1Department of Dermatology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. mitsuih-der@h.u-tokyo.ac.jp
The British Journal of Dermatology
|May 10, 2002
Abstract:
We report a Japanese patient with Hermansky-Pudlak syndrome (HPS) who developed systemic lupus erythematosus (SLE). This is the second case report of HPS complicated with SLE. A 1-bp duplication of adenine at codon 441 was found in the HPS gene, namely HPS1, which caused a frameshift. This case serves as evidence indicating that a patient with HPS can be predisposed to SLE.