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Related Experiment Videos

Antacids for obstetric patients.

G E Burgess

    American Journal of Obstetrics and Gynecology
    |November 15, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Aspiration of gastric contents is a leading cause of maternal anesthetic deaths. Oral magnesium trisilicate effectively increases gastric pH, significantly reducing aspiration risks in cesarean section patients.

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    Area of Science:

    • Anesthesiology
    • Obstetrics
    • Pharmacology

    Background:

    • Aspiration of gastric contents is the most frequent cause of anesthetic-related maternal mortality in the United States.
    • It is estimated to occur in 1 in 430 patients undergoing cesarean section under general anesthesia.
    • Pulmonary complications from aspiration can be mitigated if gastric contents have a pH greater than 2.50.

    Purpose of the Study:

    • To evaluate the efficacy of oral magnesium trisilicate in increasing gastric pH.
    • To assess its potential to prevent aspiration-related complications in obstetric patients.

    Main Methods:

    • The study involved oral administration of 30 c.c. of magnesium trisilicate to patients.
    • Gastric pH levels were measured post-administration.

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  • A control group was used for comparison.

    • Main Results:

    • Magnesium trisilicate increased gastric pH to above 2.50 in 100% of treated patients.
    • In the control group, only 60% achieved a gastric pH above 2.50.
    • This demonstrates a significant improvement in gastric acid suppression.

    Conclusions:

    • Oral preoperative or predelivery antacid therapy, specifically magnesium trisilicate, can be a valuable adjunct in managing obstetric patients.
    • It may help reduce morbidity and mortality associated with gastric aspiration.
    • It is not a substitute for comprehensive safe anesthetic management.