Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Prolidase deficiency with hyperimmunoglobulin E: a case report.

I Lopes1, L Marques, E Neves

  • 1Instituto de Genética Médica, Hospital Crianças Maria Pia, Porto, Portugal.

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
|May 10, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Linguistic and cultural adaptation of the Barcelona-2 Test in 6 Latin American dialect variants.

Neurologia·2026
Same author

Assessment of the added value of basophil activation test in immediate drug allergy diagnosis.

European annals of allergy and clinical immunology·2026
Same author

Shoulder characteristics in para athletes: A comparative analysis of range of motion, posture, and muscle function.

Rehabilitacion·2026
Same author

"Cayenne pepper" rash - A case of Schamberg disease.

Semergen·2026
Same author

Investigation into radionuclides presence and radioactivity levels in coastal sediments proximate to the Almirante Álvaro Alberto Nuclear Power Plant.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine·2025
Same author

Design of a correlation reflectometer radiometer diagnostic and measurements of the electron density-temperature cross-phase angle in the H-mode pedestal with small edge localized modes at ASDEX Upgrade.

The Review of scientific instruments·2025
Same journal

Phenotypes of atopic dermatitis in Polish children-Latent class analysis of cross-sectional questionnaire-based study.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology·2026
Same journal

Comment on Elhani et al.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology·2026
Same journal

Bridging Rare to Common Diseases: Precision Medicine and the Transforming Landscape of Pediatric Allergy and Immunology.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology·2026
Same journal

Involution of IgE sensitization to house dust mite allergen molecules by age.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology·2026
Same journal

Early initiation of inhaled corticosteroid-long-acting β<sub>2</sub>-agonist therapy and reduction of severe asthma exacerbations in high-risk preschool children: A longitudinal real-world cohort study.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology·2026
Same journal

The role of dog keeping in the home microbiota and its impact on children's health.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology·2026
See all related articles

Prolidase deficiency, a rare genetic disorder, causes skin ulcers and developmental delays. Early treatment with a special diet and supplements improved a patient's infections and skin health.

Area of Science:

  • Biochemistry
  • Immunology
  • Genetics

Background:

  • Prolidase deficiency is a rare inherited disorder.
  • It is characterized by skin ulceration, mental retardation, and imidodipeptiduria.
  • Patients often exhibit recurrent infections, distinct facial features, and splenomegaly.

Observation:

  • A case of a girl diagnosed with prolidase deficiency at 4.5 months is presented.
  • She had chronic dermatitis and recurrent respiratory infections.
  • Immunologic studies revealed elevated immunoglobulin E (IgE) and defective neutrophil chemotaxis.

Findings:

  • Treatment included a high-protein diet, ascorbic acid, manganese, and topical proline.
  • This intervention led to reduced infection frequency and severity.

Related Experiment Videos

  • Significant improvement in skin lesions was observed.

    • Implications:

    • The study highlights immunologic alterations in prolidase deficiency.
    • It demonstrates a favorable treatment outcome with a specific therapeutic regimen.
    • This case provides insights into managing prolidase deficiency and its associated immune dysfunctions.