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Related Experiment Videos

Multiple primary melanoma revisited.

M Anne Blackwood1, Robin Holmes, Marie Synnestvedt

  • 1Department of Medicine, Hematology-Oncology Division, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6145, USA.

Cancer
|May 10, 2002
PubMed
Summary

Multiple primary melanomas (MPMs) are linked to family history and CDKN2A gene mutations. Screening family members for melanoma, dysplastic nevi, and basal cell carcinoma is recommended.

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Area of Science:

  • Dermatology
  • Oncology
  • Genetics

Background:

  • Cutaneous melanoma incidence is rising globally in Caucasians.
  • Multiple primary melanomas (MPMs) occur in approximately 5% of melanoma patients, a rate significantly higher than the general population's lifetime risk.
  • Genetic predisposition is suggested for MPMs, with prior studies implicating CDKN2A mutations.

Purpose of the Study:

  • To investigate the frequency of family history of melanoma in MPM cases.
  • To characterize clinical features of MPM patients, including history of other cancers.
  • To determine the association between MPMs and functional CDKN2A mutations.

Main Methods:

  • A case series design was employed.
  • Eligible participants included patients with multiple primary invasive melanomas or an invasive primary followed by an in situ melanoma.

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  • Data were collected from patients seen in the Pigmented Lesion Clinic at the University of Pennsylvania.

    • Main Results:

    • MPM cases frequently reported a family history of melanoma, dysplastic nevi (DN), and/or other cancers (e.g., basal cell carcinoma [BCC], squamous cell carcinoma, breast cancer).
    • A personal history of DN and BCC was also common among MPM individuals.
    • Germline mutations in the CDKN2A gene were identified in 8.3% of the 96 MPM cases studied.

    Conclusions:

    • Multiple primary melanomas (MPMs) are associated with a modest incidence of family history of melanoma, DN, or BCC.
    • A small association with CDKN2A mutations was observed in MPM cases.
    • Family members of MPM index cases may benefit from screening and regular surveillance for melanoma, DN, and BCC.