Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Notching up another pathway.

Keith Brennan1, Philip Gardner

  • 1School of Biological Sciences, University of Manchester, UK. keith.brennan@man.ac.uk

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|May 10, 2002
PubMed
Summary

Notch signaling controls cell fate during development. This study reveals a novel CSL-independent pathway involving Deltex, a cytoplasmic protein, and its potential regulation by Wnt signaling.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Case Report: Drug-Induced Liver Injury from Prolonged Topical Application of Noni (<i>Morinda citrifolia</i>).

Journal of investigative medicine high impact case reports·2026
Same author

Matrix stiffness drives alterations in aldehyde metabolism, inducing DNA damage and transformation.

Scientific reports·2025
Same author

In urogenital gonorrhea, gepotidacin was noninferior to ceftriaxone + azithromycin for microbiological success.

Annals of internal medicine·2025
Same author

Abdominal aortic aneurysm screening: current effectiveness and future perspectives.

The British journal of surgery·2025
Same author

A cross-sectional survey on the effectiveness of public health campaigns for changing knowledge, attitudes, and practices in Kenyan informal settlements during the COVID-19 pandemic.

PloS one·2023
Same author

RAC1B function is essential for breast cancer stem cell maintenance and chemoresistance of breast tumor cells.

Oncogene·2023

Area of Science:

  • Developmental Biology
  • Cell Signaling
  • Molecular Biology

Background:

  • Notch proteins are crucial for cell fate determination in development.
  • A well-established model involves Notch signaling through CSL (CBF1, Suppressor of Hairless, Lag-1) transcription factors.
  • Emerging evidence suggests alternative Notch signaling pathways exist.

Purpose of the Study:

  • To investigate potential CSL-independent Notch signaling pathways.
  • To identify novel components involved in Notch signal transduction.
  • To explore the role of Deltex and Wnt signaling in Notch pathways.

Main Methods:

  • Experimental investigation of Notch signaling mechanisms.
  • Analysis of protein interactions and signaling cascades.
  • Utilizing genetic and molecular biology techniques.

Main Results:

  • Provided compelling evidence for a CSL-independent Notch signaling pathway.
  • Demonstrated the requirement of the cytoplasmic protein Deltex for this pathway.
  • Showed that Wnt signaling may regulate the Deltex-dependent Notch signal.

Conclusions:

  • Notch signaling can operate independently of the canonical CSL transcription factor pathway.
  • Deltex is a key mediator in this alternative Notch signaling route.
  • Wnt signaling represents a potential regulatory input for Deltex-mediated Notch signaling.

Related Experiment Videos