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Updated: Aug 17, 2026

In vitro Assessment of Myocardial Protection following Hypothermia-Preconditioning in a Human Cardiac Myocytes Model
Published on: October 27, 2020
[Hypothyroidism protects the myocardium against ischemia-reperfusion injury]
Israel Bobadilla1, Martha Franco, David Cruz
1Departamento de Bioquímica, Instituto Nacional de Cardiología Ignacio Chávez, INCICH, Juan Badiano No. 1, Col. Sección XVI, Tlalpan, 14080 México, D. F.
Abstract:
This work describes experimental results indicating that mitochondria from hypothyroid rats are resistant to suffer membrane permeability transition as induced by matrix calcium accumulation. It is also shown that hypothyroidism provides resistance to myocardial reperfusion injury, after a period of 5 min ischemia. It is concluded that the protection is due to a low expression of mitochondrial proteins, as well as to a lack in cardiolipin as constituent of the lipid bilayer of the inner mitochondrial membrane.
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