Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cellular effects of heavy charged particles.

P Todd1, C B Schroy, W Schimmerling

  • 1Life Sciences Building, Pennsylvania State University, University Park, Penn., USA.

Life Sciences and Space Research
|January 1, 1973
PubMed
Summary

A single heavy ion can inactivate human cells if it deposits over 3500 MeV cm-1 energy. This irreversible cell inactivation is most probable at the end of the ion

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Automatic Segmentation of Breast Carcinomas from DCE-MRI using a Statistical Learning Algorithm.

Proceedings. IEEE International Symposium on Biomedical Imaging·2017
Same author

Real-time computed tomography-based augmented reality for natural orifice transluminal endoscopic surgery navigation.

The British journal of surgery·2012
Same author

Augmented environments for minimally invasive therapy: implementation barriers from technology to practice.

Studies in health technology and informatics·2012
Same author

Metabolic burden in recombinant CHO cells: effect ofdhfr gene amplification andlacZ expression.

Cytotechnology·2012
Same author

The epidemiology of general paediatric outpatients referrals: 1988 and 2006.

Child: care, health and development·2011
Same author

Image Registered Gastroscopic Ultrasound (IRGUS) in human subjects: a pilot study to assess feasibility.

Endoscopy·2011

Area of Science:

  • Cell biology
  • Radiation biology
  • Biophysics

Background:

  • Heavy ions can cause significant cellular damage.
  • Understanding cell inactivation mechanisms is crucial for radiation protection and therapy.
  • The relationship between energy deposition and cell inactivation requires further elucidation.

Purpose of the Study:

  • To investigate the threshold of energy deposition by heavy ions that causes irreversible reproductive inactivation of human cells.
  • To correlate cell inactivation probability with nuclear size and ion trajectory.
  • To validate theoretical calculations of ion path length for cell inactivation.

Main Methods:

  • Irradiation of three-dimensional human cell cultures with high-energy nitrogen ions (3.9 GeV).
  • Analysis of cell inactivation probability in relation to nuclear area and ion energy deposition.
  • Utilizing stopping power theory to calculate ion path length for inactivation.

Main Results:

  • A single heavy ion inactivates human cells when energy deposition exceeds approximately 3500 MeV cm-1.
  • Cell inactivation probability correlates with nuclear area, indicating size-dependent sensitivity.
  • Maximum inactivation probability occurs within the final 0.5 cm of the ion's trajectory.
  • Experiments confirm theoretical predictions regarding ion path length and inactivation.

Conclusions:

  • Heavy ion passage through the nucleus at high energy deposition rates causes irreversible cell inactivation.
  • The localized nature of inactivation along the ion path has implications for spatially correlated cellular effects.
  • Observed abnormalities in Zea seedlings suggest amplification of these effects in organized cell systems.

Related Experiment Videos