Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Types of Toxins01:36

Types of Toxins

3.9K
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
3.9K
Toxic Reactions: Overview01:26

Toxic Reactions: Overview

3.2K
When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
3.2K
Lethal Alleles02:41

Lethal Alleles

18.7K
Agouti: A Lethal Allele
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
18.7K
Cancer Prevention02:59

Cancer Prevention

8.6K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
8.6K
Other Pulmonary Disorders01:17

Other Pulmonary Disorders

1.8K
Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
1.8K
Physical Properties of Amines01:26

Physical Properties of Amines

4.3K
Amines with low molecular weight are usually gaseous at room temperature, while those with high molecular weight are liquid or solids in nature. Usually, low molecular weight amines have a rotten fish-like smell. Diamines typically have a pungent smell. For instance, cadaverine and putrescine, depicted in Figure 1, are two molecules responsible for decaying tissue.
4.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Jock McCulloch (1945-2018): A Tribute.

International journal of health services : planning, administration, evaluation·2018
Same author

Oil on the water: Government regulation of a carcinogen in the twentieth-century Lancashire cotton spinning industry.

Business history·2010
Same author

Code of Sustainable Practice in Occupational and Environmental Health and Safety for Corporations.

International journal of occupational and environmental health·2008
Same author

Science is not sufficient: Irving J. Selikoff and the asbestos tragedy.

New solutions : a journal of environmental and occupational health policy : NS·2008
Same author

Shooting the messenger: the vilification of Irving J. Selikoff.

International journal of health services : planning, administration, evaluation·2007
Same author

Hero or villain?--Sir Richard Doll and occupational cancer.

International journal of occupational and environmental health·2007

Related Experiment Video

Updated: Mar 9, 2026

A Silicosis Mouse Model Established by Repeated Inhalation of Crystalline Silica Dust
10:45

A Silicosis Mouse Model Established by Repeated Inhalation of Crystalline Silica Dust

Published on: January 6, 2023

3.0K

Asbestos and its lethal legacy.

Geoffrey Tweedale1

  • 1Centre for Business History, Business School, Manchester Metropolitan University, UK. G.Tweedale@mmu.ac.uk

Nature Reviews. Cancer
|May 11, 2002
PubMed
Summary

Asbestos exposure is a significant occupational health risk, causing numerous cancer deaths. Despite public awareness since the 1960s, the dangers of asbestos have been known for over a century.

Area of Science:

  • Occupational Health
  • Toxicology
  • Environmental Health

Background:

  • Asbestos is a known carcinogen with severe health implications.
  • It is the leading cause of occupationally related cancer deaths.
  • Public awareness of asbestos hazards emerged in the mid-20th century.

Purpose of the Study:

  • To highlight the long-standing knowledge of asbestos's mortal health risks.
  • To contextualize the historical understanding of asbestos carcinogenicity.
  • To emphasize the disparity between public perception and scientific knowledge duration.

Main Methods:

  • Historical review of scientific and public health records.
  • Analysis of documented knowledge regarding asbestos health effects over time.

More Related Videos

Establishing a Silicosis Rat Model via Exposure of Whole-Body to Respirable Silica
05:03

Establishing a Silicosis Rat Model via Exposure of Whole-Body to Respirable Silica

Published on: October 28, 2022

1.7K
Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice
07:54

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice

Published on: December 21, 2019

7.4K

Related Experiment Videos

Last Updated: Mar 9, 2026

A Silicosis Mouse Model Established by Repeated Inhalation of Crystalline Silica Dust
10:45

A Silicosis Mouse Model Established by Repeated Inhalation of Crystalline Silica Dust

Published on: January 6, 2023

3.0K
Establishing a Silicosis Rat Model via Exposure of Whole-Body to Respirable Silica
05:03

Establishing a Silicosis Rat Model via Exposure of Whole-Body to Respirable Silica

Published on: October 28, 2022

1.7K
Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice
07:54

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice

Published on: December 21, 2019

7.4K
  • Comparison of historical scientific understanding with public awareness timelines.

    • Main Results:

    • Knowledge of asbestos as a mortal health hazard dates back at least 100 years.
    • Carcinogenic properties of asbestos have been recognized for over 50 years.
    • Public perception of asbestos as a hazard largely formed in the 1960s-1970s.

    Conclusions:

    • There is a significant historical gap between the scientific understanding of asbestos dangers and public awareness.
    • The prolonged exposure to asbestos continues to pose a critical occupational health concern.
    • Continued vigilance and education are necessary to mitigate asbestos-related health risks.