Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Effector and memory T-cell differentiation: implications for vaccine development.

Susan M Kaech1, E John Wherry, Raft Ahmed

  • 1Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA.

Nature Reviews. Immunology
|May 11, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same authorSame journal

New insights into progenitor exhausted T cell populations.

Nature reviews. Immunology·2026
Same author

Cellular immunology data enable clinical severity prediction via supervised machine learning.

iScience·2026
Same author

The critical role of the endogenous immune compartment after CAR T cell therapy in recurrent GBM.

Cell·2026
Same author

Ready-to-load MHC-I nanoparticles for high-throughput T cell screening studies.

Science advances·2026
Same author

Aberrant STAT signaling and T cell dysregulation define a targetable pediatric sepsis endotype.

The Journal of clinical investigation·2026
Same author

PD-1 blockade drug holiday improves exhausted progenitor CD8 T cell (Tpex) reinvigoration by avoiding Tpex adaptive resistance.

bioRxiv : the preprint server for biology·2026
Same journal

A guide to CAR T cell therapies: development, current status and future prospects.

Nature reviews. Immunology·2026
Same journal

Macrophages in embryonic development.

Nature reviews. Immunology·2026
Same journal

Glycolytic capacity instructs tumour vasculature and response to immunotherapy.

Nature reviews. Immunology·2026
Same journal

Vaginal NK cells limit epithelial barrier disruption during infection.

Nature reviews. Immunology·2026
Same journal

T cell engagers in autoimmune diseases.

Nature reviews. Immunology·2026
See all related articles

Antigen stimulation drives T-cell proliferation, effector function, and memory cell development. Understanding these signals optimizes vaccine strategies for improved immune responses.

Area of Science:

  • Immunology
  • Cellular Biology
  • Vaccinology

Background:

  • T-cells, including CD4+ and CD8+ subtypes, are crucial for adaptive immunity.
  • Antigen exposure initiates a developmental program in T-cells involving proliferation and functional differentiation.
  • The transition from effector to memory T-cells is critical for long-term immunity and vaccine efficacy.

Purpose of the Study:

  • To elucidate the critical signals governing T-cell commitment to proliferation and effector function.
  • To explore factors influencing the progression of T-cell differentiation pathways.
  • To discuss models of effector and memory T-cell differentiation and their implications for vaccine design.

Main Methods:

  • This study is a discussion and review of existing research and theoretical models.

Related Experiment Videos

  • It synthesizes current understanding of T-cell activation, proliferation, and differentiation.
  • Focuses on signaling pathways and regulatory factors involved in T-cell fate.

    • Main Results:

    • Antigen stimulation triggers a coordinated program of T-cell proliferation, effector function acquisition, and memory cell formation.
    • Specific signals are required for T-cells to commit to this developmental pathway.
    • Various factors can modulate the progression and outcome of T-cell differentiation.

    Conclusions:

    • A deeper understanding of T-cell development pathways provides insights into immune memory.
    • Optimizing vaccine strategies can be achieved by leveraging knowledge of T-cell signaling and differentiation.
    • This work highlights the link between fundamental immunology and practical vaccine development.