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Related Experiment Videos

Predicting local cell deformations in engineered tissue constructs: a multilevel finite element approach.

Roel G M Breuls1, Bram G Sengers, Cees W J Oomens

  • 1Eindhoven University of Technology, Department of Biomedical Engineering, The Netherlands. R.G.M.Breuls@tue.nl

Journal of Biomechanical Engineering
|May 11, 2002
PubMed
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This study uses a finite element approach to predict cell deformations in engineered tissues. Microstructural heterogeneity significantly impacts local cell deformations, causing them to exceed overall tissue changes.

Area of Science:

  • Biomedical Engineering
  • Computational Mechanics
  • Tissue Engineering

Background:

  • Engineered tissue constructs require accurate prediction of local cell behavior.
  • Understanding cell deformation is crucial for tissue function and development.
  • Microstructural details significantly influence macroscopic tissue properties.

Purpose of the Study:

  • To develop and apply a multilevel finite element approach for predicting local cell deformations in engineered tissues.
  • To investigate the impact of microstructural heterogeneity on cell deformations under compression.
  • To analyze the relationship between macroscopic tissue behavior and local cellular responses.

Main Methods:

  • Utilized a multilevel finite element (FE) approach for nonlinear analysis.

Related Experiment Videos

  • Modeled engineered tissue as an arrangement of cells embedded in a matrix material.
  • Employed computational homogenization to derive effective macroscopic tissue behavior.
  • Simulated compression of a skeletal muscle tissue construct.

    • Main Results:

    • Microstructural heterogeneity profoundly impacts local cell deformations.
    • Local cell deformations were found to significantly exceed macroscopic deformations.
    • The presence of neighboring cells and heterogeneity led to complex cell shapes.
    • Non-uniform deformations within individual cells were observed.

    Conclusions:

    • The developed finite element approach accurately predicts local cell deformations in engineered tissues.
    • Microstructural heterogeneity is a critical factor influencing cellular-level mechanical responses.
    • Computational homogenization effectively links microstructural behavior to macroscopic tissue properties.