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Related Experiment Videos

Donor-acquired sarcoidosis.

Maria L Padilla1, Gregory J Schilero, Alvin S Teirstein

  • 1Mount Sinai Medical Center, Division of Pulmonary and Critical Care Medicine, New York, NY 10029, USA. maria.padilla@mssm.edu

Sarcoidosis, Vasculitis, and Diffuse Lung Diseases : Official Journal of WASOG
|May 11, 2002
PubMed
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Donor-acquired sarcoidosis, developing in transplant recipients from unaffected donors, suggests a transmissible agent may cause sarcoidosis. Host factors are also crucial in disease development.

Area of Science:

  • Immunology
  • Transplant Medicine
  • Infectious Disease

Background:

  • Sarcoidosis is an inflammatory disease of unknown etiology.
  • Donor-acquired sarcoidosis is defined as sarcoidosis developing in transplant recipients from donors without a known history of the disease.

Purpose of the Study:

  • To review cases of donor-acquired sarcoidosis.
  • To discuss the implications for sarcoidosis etiology.
  • To explore the role of host factors in disease pathogenesis.

Main Methods:

  • Literature review of publications up to September 1999.
  • Analysis of four publications describing eight donated organs/tissues from donors with sarcoidosis.

Main Results:

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  • Eight instances of organ/tissue donation from sarcoidosis patients to recipients were identified.
  • Donor-acquired sarcoidosis supports the hypothesis of a transmissible agent, possibly infectious, causing sarcoidosis.
  • Not all recipients developed sarcoidosis, indicating the importance of host factors.

    • Conclusions:

    • Sarcoidosis may be caused by a transmissible agent.
    • Host factors play a significant role in sarcoidosis pathogenesis.
    • Host tolerance may explain the lack of mortality or allograft dysfunction in observed cases.