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Ambulatory morning growth hormone concentrations increase in men and decrease in women with age.

B Edén Engström1, F A Karlsson, T Naessén

  • 1Department of Medical Sciences, University Hospital, Uppsala, Sweden. Britt.Eden_Engstrom@medsci.uu.se

Scandinavian Journal of Clinical and Laboratory Investigation
|May 11, 2002
PubMed
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Morning growth hormone (GH) levels increase with age in men but decrease in women, reducing the gender gap. Oestradiol (E2) does not solely explain the age-related decline in women's GH.

Area of Science:

  • Endocrinology
  • Gerontology
  • Human Physiology

Background:

  • A significant 80-fold difference in median growth hormone (GH) levels exists between young adult men and women.
  • Previous studies indicate GH levels are influenced by sex and age.

Purpose of the Study:

  • To investigate the effects of aging on morning ambulatory GH levels in men and women.
  • To examine the influence of oestradiol (E2) on GH levels in postmenopausal women.

Main Methods:

  • Analysis of GH, sex hormone-binding globulin (SHBG), E2, and testosterone (T) in sera from 254 men (21-75 years) and 40 women (21-85 years).
  • Study of 19 postmenopausal women (51-79 years) treated with E2 implants.
  • Statistical analysis to determine correlations between GH, age, and hormone levels.

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Main Results:

  • GH levels increased with age in men (41-75 years) and correlated inversely with free androgen index (T/SHBG) and directly with SHBG, particularly before age 60.
  • GH levels decreased with age in women (21-85 years).
  • The gender difference in median GH levels narrowed significantly with age, from 102-fold in young adults to 12-fold in the elderly. E2 treatment in postmenopausal women did not alter GH levels compared to controls.

Conclusions:

  • Aging has opposite effects on morning GH levels in men and women, leading to a reduced gender disparity.
  • The age-related decline in GH in women is not solely attributable to decreased oestrogen levels.