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Persistent hyperinsulinemic hypoglycemia of infancy--successful therapy with nifedipine
Preeti Shanbag1, Ashish Pathak, Mamta Vaidya
1Pediatric Intensive Care Unit, Lokmanya Tilak Municipal Medical College & General Hospital, Sion, Mumbai, India. pshanbag@yahoo.com
Indian Journal of Pediatrics
|May 11, 2002
Insights
Calcium channel blockers may treat persistent hyperinsulinemic hypoglycemia of infancy (PHHI). A 30-day-old infant with PHHI was successfully treated with oral nifedipine alone.
Area of Science:
- Neonatal Medicine
- Pediatric Endocrinology
Background:
- Persistent hyperinsulinemic hypoglycemia of infancy (PHHI) is a rare but serious condition.
- Current treatment options for PHHI can be invasive or have significant side effects.
Observation:
- A 30-day-old infant presented with symptoms of PHHI.
- The infant's condition was refractory to initial management.
Findings:
- Successful treatment of PHHI was achieved using oral nifedipine.
- Nifedipine, a calcium channel blocker, demonstrated efficacy as a sole therapeutic agent.
Implications:
- Oral nifedipine represents a potential novel therapeutic strategy for PHHI.
- This finding may reduce the need for more aggressive interventions in infants with PHHI.
Abstract:
Recent studies have demonstrated a role for calcium channel blocking agents in the treatment of persistent hyperinsulinemic hypoglycemia of infancy. We report a 30 day old infant with PHHI whom we successfully treated with oral nifedipine alone.