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Intercellular junctions of rat endocardium.

P Anversa, J Giacomelli, J Wiener

    The Anatomical Record
    |November 1, 1975
    PubMed
    Summary
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    Rat endocardial ultrastructure reveals intercellular junctions, including gap junctions, influencing permeability. These findings explain macromolecule diffusion across the endocardium.

    Area of Science:

    • Cardiovascular Biology
    • Cell Biology
    • Histology

    Background:

    • The endocardium forms the inner lining of the heart chambers.
    • Understanding endocardial ultrastructure is crucial for elucidating cardiac function and disease.

    Purpose of the Study:

    • To characterize the ultrastructure of intercellular junctions in rat endocardium.
    • To investigate the role of these junctions in endocardial permeability.

    Main Methods:

    • In vitro lanthanum exposure of rat endocardium.
    • Uranyl acetate staining en bloc for electron microscopy.

    Main Results:

    • Identified interendothelial clefts with varying courses and focal membrane appositions/fusions.
    • Discovered elongate restrictions with hexagonal arrays, identified as gap junctions.

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  • Observed endocardial clefts lacking occlusive foci.

    • Conclusions:

    • The absence of occlusive foci in interendothelial clefts explains ventricular endocardial permeability.
    • Pressure gradients likely drive macromolecule diffusion between the ventricle and myocardium.
    • The presence of gap junctions suggests potential roles in electrical phenomena within the endocardium.