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Related Experiment Videos

Microscopic colitis: a review.

Darrell S Pardi1, Thomas C Smyrk, William J Tremaine

  • 1Division of Gastroenterology and Hepatology, Mayo Clinic and Foundation, Rochester, Minnesota, USA.

The American Journal of Gastroenterology
|May 11, 2002
PubMed
Summary

Microscopic colitis causes chronic watery diarrhea and abdominal pain. Diagnosis requires microscopic examination, revealing intraepithelial lymphocytosis and inflammation, with subtypes distinguished by collagen bands.

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Area of Science:

  • Gastroenterology
  • Pathology

Background:

  • Microscopic colitis is a frequent cause of chronic watery diarrhea.
  • Symptoms include abdominal pain and weight loss.
  • Gross colonic mucosa appears normal.

Purpose of the Study:

  • To summarize the key features of microscopic colitis.
  • To differentiate between collagenous and lymphocytic colitis.
  • To discuss diagnostic criteria and treatment approaches.

Main Methods:

  • Diagnosis relies on histological examination of colonic biopsies.
  • Key findings include intraepithelial lymphocytosis and lamina propria inflammation.
  • Subtypes are differentiated by subepithelial collagen band thickness.

Main Results:

Related Experiment Videos

  • Collagenous colitis shows a thickened subepithelial collagen band.
  • Lymphocytic colitis lacks this thickened band.
  • Both subtypes share clinical and histological similarities.

Conclusions:

  • Microscopic colitis diagnosis requires histological confirmation.
  • While pathophysiological mechanisms are debated, treatment can effectively manage symptoms.
  • Further randomized trials are needed.