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Resistant hypertension.

David A Calhoun1, Mohammad A Zaman, Mari K Nishizaka

  • 1Vascular Biology and Hypertension Program, University of Alabama at Birmingham, 520 ZRB, 703 South 19th Street, Birmingham, AL 35294, USA. dcalhoun@uab.edu

Current Hypertension Reports
|May 11, 2002
PubMed
Summary
This summary is machine-generated.

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Resistant hypertension is common, often due to factors like age, obesity, and medication issues. Effective management requires identifying and treating underlying causes and using combination drug therapy.

Area of Science:

  • Cardiology
  • Nephrology
  • Pharmacology

Background:

  • Resistant hypertension is a growing clinical challenge, frequently characterized by uncontrolled systolic blood pressure.
  • Factors like older age, obesity, and renal insufficiency contribute to poor blood pressure control.
  • Medication non-adherence and interfering exogenous substances (e.g., NSAIDs) are common causes of treatment resistance.

Purpose of the Study:

  • To review the common contributing factors and secondary causes of resistant hypertension.
  • To emphasize the importance of identifying and addressing these factors for effective management.
  • To highlight current therapeutic strategies for resistant hypertension.

Main Methods:

  • Review of recent clinical trials and reports on resistant hypertension.

Related Experiment Videos

  • Analysis of factors associated with uncontrolled blood pressure.
  • Discussion of diagnostic considerations for secondary causes.
  • Evaluation of pharmacologic treatment approaches.

    • Main Results:

    • Persistent systolic blood pressure elevation is typical in uncontrolled hypertension.
    • Older age, obesity, and renal insufficiency are linked to poorer blood pressure control.
    • Primary aldosteronism is increasingly recognized as a common secondary cause of hypertension.
    • Nonsteroidal anti-inflammatory drugs, oral contraceptives, and sympathomimetics can impede treatment.

    Conclusions:

    • Effective treatment necessitates identifying and reversing contributing factors and secondary causes.
    • Combination pharmacologic therapy, including a long-acting diuretic, is recommended.
    • Primary aldosteronism should be considered in all patients with resistant hypertension.