The "imaged-desmosome": a component of intercalated discs in embryonic guinea pig myocardium

A heretofore undescribed structural variation of the desmosomes of the intercalated disc is found in myocardial cells of the embryonic guinea pig. These desmosomes consist of the usual pair of opaque leaflets, each of the pair contributed by one of the apposed muscle cells. In addition, in the cytoplasm of one of the cells there appears a pair of linear densities (facsimile-lines) parallel to the nearest desmosomal plaque and separated from it by a 60 mm space. The facsimile lines superficially resemble the desmosomal leaflets in length and thickness, thus forming a cytoplasmic "image" of the desmosome. These "imaged-desmosomes" are found predominantly in the longitudinally-running portions of the intercalated discs and are common in 7-week embryos. Their incidence drops sharply by eight weeks of gestation, and they are virtually absent from the heart of the newborn animal. Often tubules of the sarcoplasmic reticulum (SR) are found in apposition to the facsimile-lines; thus it appears that association of SR tubules with desmosomes is responsible for the formation of imaged-desmosomes.