Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Myoglobin polymorphism in the pollan (Osteichthyes: Coregoninae).

A Ferguson

    Animal Blood Groups and Biochemical Genetics
    |January 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Every child, every day, back to play: the PICUstars protocol - implementation of a nurse-led PICU liberation program.

    BMC pediatrics·2022
    Same author

    Analysis of misses in imaging of head and neck pathology by attending neuroradiologists at a single tertiary academic medical centre.

    Clinical radiology·2021
    Same author

    COVID-19-induced toxic epidermal necrolysis.

    Clinical and experimental dermatology·2021
    Same author

    Randomized controlled trial of topical corticosteroid and home-based narrowband ultraviolet B for active and limited vitiligo: results of the HI-Light Vitiligo Trial.

    The British journal of dermatology·2020
    Same author

    An economic evaluation of the randomized controlled trial of topical corticosteroid and home-based narrowband ultraviolet B for active and limited vitiligo (the HI-Light Vitiligo Trial).

    The British journal of dermatology·2020
    Same author

    Convolutional Neural Network-Based Automated Segmentation of the Spinal Cord and Contusion Injury: Deep Learning Biomarker Correlates of Motor Impairment in Acute Spinal Cord Injury.

    AJNR. American journal of neuroradiology·2019
    Same journal

    Quantitative analyses of haemoglobin types in Australian horses.

    Animal blood groups and biochemical genetics·1985
    Same journal

    A new case of blood cell chimerism in pigs.

    Animal blood groups and biochemical genetics·1985
    Same journal

    Equine lymphocyte antigens in four major Belgian horse populations. Contribution to serology and antigen distribution.

    Animal blood groups and biochemical genetics·1985
    Same journal

    Serum and tissue alkaline phosphatases in pigs.

    Animal blood groups and biochemical genetics·1985
    Same journal

    Distribution of complement protein C4 concentrations in bovine plasma.

    Animal blood groups and biochemical genetics·1985
    Same journal

    Procedure for simultaneous phenotyping of genetic variants in cow's milk by isoelectric focusing.

    Animal blood groups and biochemical genetics·1985
    See all related articles

    Genetic analysis of Irish pollan (Coregonus pollan) revealed three myoglobin phenotypes controlled by two alleles. Allele frequencies were consistent across isolated lakes, with a notable excess of heterozygotes suggesting balanced polymorphism.

    Area of Science:

    • * Population genetics
    • * Molecular evolution
    • * Fish biology

    Background:

    • * Myoglobin is a crucial protein for oxygen transport in muscle tissue.
    • * Electrophoretic analysis is a common method for studying protein polymorphism.
    • * Understanding genetic diversity in fish populations is vital for conservation and evolutionary studies.

    Purpose of the Study:

    • * To investigate the genetic basis of myoglobin variation in the Irish pollan (Coregonus pollan).
    • * To determine allele frequencies and heterozygote excess in geographically isolated populations.
    • * To assess the mode of inheritance and potential selective pressures maintaining myoglobin polymorphism.

    Main Methods:

    • * Electrophoretic separation of myoglobin from heart and lateral line muscle tissue.

    Related Experiment Videos

  • * Analysis of myoglobin phenotypes to infer genotypes.
  • * Statistical analysis of allele frequencies and Hardy-Weinberg equilibrium.

    • Main Results:

    • * Identified three distinct electrophoretically separable myoglobin phenotypes in Irish pollan.
    • * Demonstrated that this polymorphism is controlled by two co-dominant alleles.
    • * Observed virtually identical allele frequencies in two lakes isolated since the last Ice Age, with a significant excess of heterozygotes in both.

    Conclusions:

    • * The observed myoglobin polymorphism in Irish pollan is likely balanced.
    • * Heterozygote superiority is proposed as the mechanism maintaining this genetic variation.
    • * This finding provides insights into the evolutionary dynamics of isolated fish populations.