Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Endothelium: interface between coagulation and inflammation.

Marcel Levi1, Hugo ten Cate, Tom van der Poll

  • 1Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, The Netherlands.

Critical Care Medicine
|May 11, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Current opinion: the OCEANIC trial journey: from failure to breakthrough?

European heart journal. Cardiovascular pharmacotherapy·2026
Same author

Antidotes for Anticoagulation Reversal.

The New England journal of medicine·2026
Same author

Intrinsic activated thrombin generation for treatment efficacy and monitoring of octocog alfa and emicizumab in severe hemophilia A.

Research and practice in thrombosis and haemostasis·2026
Same author

Inhibition of inflammation reduces hypofibrinolysis in severe COVID-19: A nested case-control study within the MaastrICCht cohort.

Thrombosis research·2026
Same author

Thrombin generation and the pharmacodynamics of parenteral anticoagulants.

Pharmacological reviews·2026
Same author

Andexanet alfa for the reversal of anticoagulation: Dutch practice data.

Research and practice in thrombosis and haemostasis·2026
Same journal

The authors reply.

Critical care medicine·2026
Same journal

Attracting Emergency Medicine Graduates to Surgical Critical Care Training Programs.

Critical care medicine·2026
Same journal

The authors reply.

Critical care medicine·2026
Same journal

Beyond a Snapshot: Tracking Family Prognostic Expectations in the ICU.

Critical care medicine·2026
Same journal

The authors reply.

Critical care medicine·2026
Same journal

Plasma Levels of Soluble ST2 Reflect Extrapulmonary Organ Dysfunction and Predict Outcomes in Acute Respiratory Failure: Beware of Potential Confounders.

Critical care medicine·2026
See all related articles

Endothelial cells are central to severe infection-related coagulation issues, influencing thrombin generation and fibrinolysis. Inflammation and coagulation crosstalk heavily involves the endothelium, impacting hemostasis.

Area of Science:

  • Vascular Biology
  • Hemostasis and Thrombosis
  • Infectious Diseases

Background:

  • Severe infections trigger complex interactions between the immune system and the coagulation cascade.
  • Endothelial dysfunction is increasingly recognized as a key factor in sepsis-induced coagulopathy.

Purpose of the Study:

  • To review the role of endothelial cells in coagulation abnormalities during severe infection.
  • To examine the influence of proinflammatory cytokines on these mechanisms.
  • To understand the crosstalk between coagulation and inflammation.

Main Methods:

  • Systematic review of published literature.
  • Inclusion of experimental studies on coagulation activation during inflammation.
  • Inclusion of clinical studies on sepsis and hemostatic abnormalities.

Related Experiment Videos

Main Results:

  • Endothelial cells are pivotal in initiating and regulating thrombin generation.
  • The endothelium plays a central role in the inhibition of fibrinolysis.
  • Severe inflammation leads to significant hemostatic derangements primarily involving endothelial pathways.

Conclusions:

  • The endothelium is a central player in the pathogenesis of hemostatic derangement during severe inflammation.
  • The interaction between inflammation and coagulation is bidirectional, with the endothelium mediating significant crosstalk.