Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Endothelial cell apoptosis in sepsis.

Richard S Hotchkiss1, Kevin W Tinsley, Paul E Swanson

  • 1Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO, USA.

Critical Care Medicine
|May 11, 2002
PubMed
Summary

Endothelial cell apoptosis plays a role in sepsis pathogenesis. While in vitro studies show this, in vivo evidence is limited, and its impact on survival varies by pathogen.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Stemness as the Engine of Checkpoint Durability.

The New England journal of medicine·2026
Same author

Host-directed immune therapies: a second front in the battle against sepsis.

The Journal of clinical investigation·2026
Same author

Clinicopathologic characteristics of rare appendiceal collision tumors: A multi-center case series and literature review.

Annals of diagnostic pathology·2026
Same author

Prevention of secondary infections by interferon-gamma in ICU-acquired sustained immune suppression in France: study protocol of the PLATINIUM randomised trial.

BMJ open·2026
Same author

IL-7: a potential next-generation adjuvant for immune cell therapies.

Frontiers in immunology·2026
Same author

Quantifying Nuance Within Sepsis-Associated Immune Suppression Toward Diagnostic Certainty.

Shock (Augusta, Ga.)·2025

Area of Science:

  • Cellular Biology
  • Pathophysiology
  • Immunology

Background:

  • Sepsis involves widespread inflammation and organ dysfunction.
  • Endothelial cells form the inner lining of blood vessels and are crucial for vascular integrity.
  • Apoptosis, or programmed cell death, is a regulated cellular process.

Purpose of the Study:

  • To explore the potential involvement of endothelial cell apoptosis in the development of sepsis.
  • To review existing literature on endothelial cell apoptosis in the context of sepsis and endotoxemia.

Main Methods:

  • Literature review of published studies in biomedical journals.
  • Inclusion of studies from the authors' own laboratory research.
  • Analysis of both in vitro and in vivo experimental models of endotoxin exposure and sepsis.

Related Experiment Videos

Main Results:

  • Apoptosis is a known mechanism for lymphocyte and gastrointestinal epithelial cell death in sepsis.
  • In vitro studies suggest certain pathogens can induce endothelial cell apoptosis.
  • Direct evidence of endothelial cell apoptosis in in vivo sepsis models is currently lacking.

Conclusions:

  • Detecting endothelial cell apoptosis in vivo is challenging due to rapid clearance of apoptotic cells.
  • The role of endothelial cell apoptosis in sepsis may be context-dependent, potentially influencing host survival.
  • Further research is needed to fully elucidate the in vivo significance of endothelial cell apoptosis in sepsis.