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Statistical analysis of the relationship between translation initiation AUG context and gene expression level in
Hitoshi Miyasaka1, Shozo Kanai, Satoshi Tanaka
1The Kansai Electric Power Co, Technical Research Center, Amagasaki, Hyogo, Japan. K448482@kepco.co.jp
Bioscience, Biotechnology, and Biochemistry
|May 15, 2002
Abstract:
The preference for the optimal nucleotide of the mammalian translation initiation AUG context [GCCGCC(A/G)CCaugG] is generally more pronounced in the highly expressed genes than in the transcription factor genes at the -9 through -1 positions in humans. The influence of amino acid preference on the nucleotide choice at the +4 position was also examined.