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Related Experiment Videos

Occlusion vs. skin barrier function.

Hongbo Zhai1, Howard I Maibach

  • 1Department of Dermatology, University of California, School of Medicine, San Francisco 94143-0989, USA.

Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [And] International Society for Digital Imaging of Skin (ISDIS) [And] International Society for Skin Imaging (ISSI)
|May 15, 2002
PubMed
Summary
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Skin occlusion can increase chemical absorption and compromise skin barrier function by increasing hydration. However, optimal hydrocolloid materials can mitigate these negative effects.

Area of Science:

  • Dermatology
  • Skin Physiology
  • Biotechnology

Background:

  • Skin occlusion enhances percutaneous absorption of chemicals.
  • Occlusion impairs skin barrier function by obstructing ventilation and increasing hydration.

Purpose of the Study:

  • To review the effects of skin occlusion on skin barrier function.
  • To highlight the role of objective skin bioengineering technologies in assessing these effects.

Main Methods:

  • Literature review focusing on skin occlusion.
  • Analysis of studies utilizing objective skin bioengineering technology.

Main Results:

  • Occlusion generally increases percutaneous absorption.
  • Stratum corneum hydration increases under occlusion, compromising barrier function.

Related Experiment Videos

  • Skin bioengineering provides objective measures of occlusion's effects.

    • Conclusions:

    • Various techniques define occlusion's impact on skin barrier function.
    • Hydrocolloid materials can manage excess water and reduce adverse occlusion effects.