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Haemodynamic limitations and exercise performance in peripheral arterial disease.

S Green1

  • 1Deportment of Physiology, Trinity College, University of Dublin, Ireland. sgreen@tcd.ie

Clinical Physiology and Functional Imaging
|May 15, 2002
PubMed
Summary

Haemodynamic limitations are not poor predictors of exercise performance in peripheral arterial disease (PAD) and intermittent claudication. Measuring blood flow during exercise is most valuable for predicting performance in claudicants.

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Area of Science:

  • Vascular Medicine
  • Exercise Physiology

Background:

  • Peripheral arterial disease (PAD) and intermittent claudication are often associated with poor exercise performance.
  • The predictive value of haemodynamic limitations on exercise capacity in PAD patients remains debated.

Purpose of the Study:

  • To review published data on the relationship between haemodynamic limitations and exercise performance in intermittent claudication.
  • To evaluate the methodological limitations of studies assessing haemodynamic predictors of exercise capacity.

Main Methods:

  • Systematic review of existing literature.
  • Analysis of data concerning resting ankle-brachial index (ABI) and blood flow measurements.
  • Evaluation of blood flow during various exercise protocols (walking, cycling, calf exercise).

Main Results:

  • Data on resting ABI and post-exercise blood flow offer limited explanatory value for exercise performance differences.
  • Blood flow measurements obtained during actual walking or cycling exercise are more valuable.
  • Methodological limitations in existing studies impact the interpretation of haemodynamic data.

Conclusions:

  • Haemodynamic measurements during exercise are superior predictors of exercise performance in claudicants compared to resting or post-exercise measures.
  • The argument that haemodynamic limitations are poor predictors of exercise performance in PAD is not supported by current evidence.
  • Accurate assessment of haemodynamic function during functional activities is crucial for understanding exercise limitations in PAD.