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Lysozyme in corneal ulcer.

K S Mehra, R Singh, R P Bhatia

    Annals of Ophthalmology
    |November 1, 1975
    PubMed
    Summary
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    Lysozyme eye drops significantly accelerated corneal ulcer healing in rabbits when combined with chloramphenicol. This combination therapy offers a promising approach for treating staphylococcal corneal ulcers.

    Area of Science:

    • Ophthalmology
    • Microbiology
    • Pharmacology

    Background:

    • Bacterial keratitis, specifically staphylococcal corneal ulcers, poses a significant threat to vision.
    • Chloramphenicol is a common antibiotic for bacterial eye infections, but enhanced treatment strategies are needed.
    • Lysozyme, an antimicrobial enzyme, has potential therapeutic applications in ocular infections.

    Purpose of the Study:

    • To investigate the efficacy of lysozyme eye drops in accelerating the healing of staphylococcal corneal ulcers.
    • To compare the healing rates of corneal ulcers treated with lysozyme alone, chloramphenicol alone, and a combination of chloramphenicol and lysozyme.
    • To evaluate the role of lysozyme as an adjunct therapy in managing bacterial keratitis.

    Main Methods:

    • An experimental study was conducted on 16 albino rabbits with induced staphylococcal corneal ulcers.

    Related Experiment Videos

  • Treatment groups included placebo (distilled water), lysozyme 1% drops, chloramphenicol 0.4% drops, and a combination of chloramphenicol 0.4% + lysozyme 1% drops.
  • Eye drops were administered four times daily to the affected eyes.

    • Main Results:

    • Corneal ulcer healing was significantly faster in eyes treated with the combination of chloramphenicol and lysozyme drops compared to other groups.
    • Treatment with chloramphenicol alone showed a slower healing rate than the combination therapy.
    • Lysozyme drops alone or placebo did not demonstrate significant acceleration of corneal ulcer healing.

    Conclusions:

    • Lysozyme eye drops, when used adjunctively with chloramphenicol, markedly enhance the healing process of staphylococcal corneal ulcers.
    • The combination therapy demonstrates superior efficacy over monotherapy with chloramphenicol or lysozyme.
    • Lysozyme shows potential as a valuable component in the treatment of bacterial keratitis.