Transcription factors and neoplasia: vistas in novel drug design

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Updated: Oct 1, 2026

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis
09:58

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis

Published on: June 27, 2020

Mihalis V Karamouzis1, Vassilis G Gorgoulis, Athanasios G Papavassiliou

  • 1Department of Biochemistry, School of Medicine, University of Patras, GR-26110, Greece.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
|May 15, 2002
PubMed
Abstract

Insights

Transcription factors are key regulators of cell processes and are emerging as promising targets for novel anticancer drugs. This approach holds potential to significantly advance cancer treatment options.

Area of Science:

  • Molecular Biology
  • Pharmacology
  • Oncology

Background:

  • Transcription factors regulate critical cellular processes including growth, differentiation, and apoptosis.
  • Their role in disease, particularly cancer, has spurred interest in their therapeutic potential.

Purpose of the Study:

  • To explore transcription factors as pharmaceutical targets for cancer therapy.
  • To leverage advancements in drug design and genomics for developing novel anticancer agents.

Main Methods:

  • Structure-based drug design
  • Computer-aided modeling
  • Functional genomics and proteomics

Main Results:

  • Integration of molecular data with advanced technologies facilitates the development of targeted therapies.
  • Identification of novel strategies for highly selective drug discovery.

Conclusions:

  • Transcription factor-targeted therapies represent a promising frontier in oncology.
  • This approach could revolutionize current anticancer drug options and expand the clinical armamentarium.

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