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Effects of thyroid hormone on mRNAs of phosphoglycerate mutase subunits in rat muscle during development
Núria González-Cinca1, Sergio Gonzalo, Carlos Ascaso
1Unitat de Bioquimica, Departament de Ciéncies Fisiològiques I, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Facultat de Medicina, Universitat de Barcelona, Spain.
Background:
We previously showed that triiodothyronine (T3) stimulates muscle phosphoglycerate mutase (PGAM) activity and isozyme transition in rat skeletal and cardiac muscles.
Methods:
The effects of T3 on PGAM types B and M subunit expression in rat muscle during development are reported.
Results:
T3 administration during the first 21 days of rat life more than doubles type M PGAM mRNA levels, but produces minor effects on type B PGAM mRNA levels. The antihormone propylthiouracil (PTU) slightly decreases both type B and M mRNA levels, but this decrease is not statistically significant.
Conclusion:
Thyroid hormone influences PGAM mRNA isozyme levels differently and increases type M mRNA.
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