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Mitosis: aurora gives chromosomes a healthy stretch
1Department of Molecular and Cell Biology, Harvard University, 16 Divinity Ave, Room 3000, Cambridge, MA 02138, USA. bstern@mcb.harvard.edu
Current Biology : CB
|May 15, 2002
Abstract:
Attachment of sister chromatids to microtubules from opposite spindle poles--bi-orientation--generates tension at the kinetochores. The Ipl1/Aurora B kinase responds to the absence of tension at mono-oriented chromosomes and promotes microtubule turnover and spindle checkpoint activation until a stable bi-oriented attachment is achieved.