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Asthma: T-bet--a master controller?
Douglas S Robinson1, Clare M Lloyd
1Department of Allergy, National Heart and Lung Institute, Biomedical Sciences Division, Faculty of Medicine, Imperial College, London SW7 2AZ, UK. d.s.robinson@ic.ac.uk
Current Biology : CB
|May 15, 2002
Abstract:
The transcription factors T-bet and GATA3 are important reciprocal determinants of Th1 and Th2 T helper cell differentiation. Recent evidence suggests that these factors may affect airway immunopathology in asthma.