Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Population genomics: ageing by association.

Scott D Pletcher1, Michael P H Stumpf

  • 1Galton Laboratory, Department of Biology, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK. s.pletcher@ucl.ac.uk

Current Biology : CB
|May 15, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Molecular noise modulates transitions in the cell-fate differentiation landscape.

NPJ systems biology and applications·2026
Same author

Fifty years since a simple equation described the chaos of biology.

Nature·2026
Same author

Learning cell-specific networks from dynamics and geometry of single cells.

Cell systems·2025
Same author

Towards a mathematical framework for modelling cell fate dynamics.

Journal of mathematical biology·2025
Same author

Regenerate to "Rejuvenate": Insights From Adult Resident Stem Cells of Aged Flatworms and Mice.

Aging cell·2025
Same author

The topological properties of the protein universe.

Nature communications·2025
Same journal

Hunting ecology predicts eye arrangements in the modular visual system of spiders.

Current biology : CB·2026
Same journal

Sub-second fluctuations between top-down and bottom-up modes distinguish diverse human brain states.

Current biology : CB·2026
Same journal

Queen bees offload pesticide burden to eggs when social buffering is overwhelmed.

Current biology : CB·2026
Same journal

Pitch selectivity in ferret auditory cortex.

Current biology : CB·2026
Same journal

A cell size-dependent competition between geometry and polarity governs nuclear and spindle positioning in early embryos.

Current biology : CB·2026
Same journal

Trophic cascades drive sustainability in the agricultural heritage rice-fish coculture system.

Current biology : CB·2026
See all related articles

Mutations in the Klotho gene cause premature aging in mice. Studies show a Klotho gene variant is linked to human lifespan, highlighting the potential of aging research.

Area of Science:

  • Genetics
  • Aging Research
  • Molecular Biology

Background:

  • The Klotho gene plays a critical role in aging processes.
  • Mutations in Klotho are known to cause premature aging phenotypes in model organisms like mice.

Purpose of the Study:

  • To investigate the association between genetic variations in the Klotho gene and human lifespan.
  • To explore the potential of human genetic variation studies in understanding the biology of aging.

Main Methods:

  • Analysis of human genetic variation data.
  • Association study to link specific Klotho gene alleles with lifespan.

Main Results:

  • An association was identified between a specific Klotho gene allele and human lifespan.

Related Experiment Videos

  • This finding supports the role of Klotho in human aging.

    • Conclusions:

    • The Klotho gene is a significant factor in human aging.
    • Association studies of human genetic variation offer powerful insights into aging mechanisms and lifespan.