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Cell cycle: stressed out of mitosis
Alexei Mikhailov1, Conly L Rieder
1Division of Molecular Medicine, Wadsworth Center, New York State Dept. of Health, Albany, NY 12201-0509, USA.
Current Biology : CB
|May 15, 2002
Abstract:
Cells in early stages of chromosome condensation are very vulnerable, and many stresses that do not damage DNA induce a transient return to late G2 phase. Such stresses include the drug-induced disassembly of microtubules, which triggers an ATM-independent G2 checkpoint pathway involving a novel ubiquitin ligase.