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Photochromic nucleic base units suitable for nucleic acid labelling
Eliso Gogritchiani1, Thomas Hartmann, Barbara Susanne Palm
1Universität des Saarlandes, Fakultät 8.12, Organische Chemie, Im Stadtwald, D-66123, Saarbrücken, Germany.
Abstract:
New molecules incorporating a uracil nucleic base and a dihydroindolizine (DHI) unit linked via spacer arms, i.e., uracil-spyrodihydroindolizine (4), were synthesised as models for light sensitive systems for nucleic acid labelling. The uracil-DHI (4) undergoes easy photocoloration to the uracil-betaine (5) generating the UV-detectable species. Preliminary results show rather weak binding of uracil-DHI (4) to calf thymus-DNA.