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Fatal buckwheat dependent exercised-induced anaphylaxis
1Department of Pediatrics, Kitasato University School of Medicine, Kanagawa, Japan.
Asian Pacific Journal of Allergy and Immunology
|May 15, 2002
Summary
A rare case of fatal food-dependent exercise-induced anaphylaxis (FEA) linked to buckwheat consumption is detailed. This study highlights buckwheat as a potential trigger for severe allergic reactions, emphasizing the need for awareness.
Area of Science:
- Allergy and Immunology
- Clinical Pathology
- Forensic Medicine
Background:
- Food-dependent exercise-induced anaphylaxis (FEA) is a rare condition.
- Buckwheat-induced FEA is exceptionally uncommon.
- This report presents a unique fatal case.
Observation:
- An 8-year-old girl experienced anaphylaxis after consuming buckwheat noodles and exercising.
- Symptoms included abdominal pain, vomiting, coughing, chest discomfort, and cardiorespiratory arrest.
- Autopsy revealed digestive tract inflammation, ileal ulceration, hemorrhage, and pulmonary damage.
Findings:
- The patient had elevated IgE levels and positive IgE-radioallergosorbent test (RAST) scores for buckwheat and wheat.
- Immunoblotting identified specific buckwheat allergens in the patient's serum.
- Histopathology confirmed buckwheat-induced inflammation and tissue damage.
Implications:
- This case underscores buckwheat as a potential cause of severe, fatal FEA.
- Highlights the critical role of specific IgE testing in diagnosing buckwheat allergy.
- Emphasizes the importance of recognizing FEA triggers for preventative measures.
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