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Related Experiment Videos

Cocaine and development: a retrospective perspective.

L P Spear1, M M Silveri, M Casale

  • 1Department of Psychology and Center for Developmental Psychobiology, Binghamton University, Box 6000, State University of New York, Binghamton, NY 13902-6000, USA. lspear@binghamton.edu

Neurotoxicology and Teratology
|May 16, 2002
PubMed
Summary
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Prenatal cocaine exposure in Sprague-Dawley rats causes neurobehavioral changes in offspring, varying by age and gender. Stressful conditions can reveal altered stressor responsiveness, even in pair-fed controls.

Area of Science:

  • Neuroscience
  • Developmental Psychology
  • Pharmacology

Background:

  • Prenatal exposure to substances like cocaine can impact offspring neurodevelopment.
  • Understanding these effects is crucial for public health and developmental studies.

Purpose of the Study:

  • To review neurobehavioral alterations in Sprague-Dawley rat offspring following prenatal cocaine exposure.
  • To examine age-dependent, gender-specific, and stress-related outcomes.

Main Methods:

  • Review of studies involving Sprague-Dawley rat dams exposed to cocaine (40 mg/kg/day) during gestation (days 8-20).
  • Analysis of offspring neurobehavioral outcomes, including classical conditioning, cognitive tasks, and stressor responsiveness.
  • Comparison between cocaine-exposed (COC) and pair-fed (PF) groups.

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Main Results:

  • Offspring exhibit age-dependent neurobehavioral deficits, with early postnatal conditioning deficits and adult cognitive effects in specific tasks.
  • Adult male offspring show more alterations than females.
  • Stressful testing conditions or challenges reveal effects, including altered stressor responsiveness in some pair-fed offspring.

Conclusions:

  • Prenatal cocaine exposure induces lasting neurobehavioral changes in rat offspring.
  • Outcomes are influenced by offspring age, gender, and testing environment.
  • Premating cocaine exposure is a potential strategy to mitigate some effects, warranting further investigation.