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Low-density lipoprotein reconstituted by pyropheophorbide cholesteryl oleate as target-specific photosensitizer
Gang Zheng1, Hui Li, Min Zhang
1Department of Radiology, University of Pennsylvania Medical School, Philadelphia 19104, USA. zheng@rad.upenn.edu
Bioconjugate Chemistry
|May 16, 2002
Abstract:
To target tumors overexpressing low-density lipoprotein receptors (LDLr), a pyropheophorbide cholesterol oleate conjugate was synthesized and successfully reconstituted into the low-density lipoprotein (LDL) lipid core. Laser scanning confocal microscopy studies demonstrated that this photosensitizer-reconstituted LDL can be internalized via LDLr by human hepatoblastoma G(2) (HepG(2)) tumor cells.