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Diarrhoea following renal transplantation
Mehmet Riza Altiparmak1, Sinan Trablus, Omer Nuri Pamuk
1Department of Nephrology, Cerrahpaşa Medical Faculty, University of Istanbul, Istanbul, Turkey. onpamuk80@hotmail.com
Clinical Transplantation
|May 16, 2002
Summary
Diarrhoea in renal transplant recipients is frequently caused by infections and drugs. This condition can lead to poor clinical outcomes, including mortality, highlighting the need for prompt diagnosis and management.
Area of Science:
- Nephrology
- Transplantation
- Infectious Diseases
Background:
- Diarrhoea is a common complication in renal transplant recipients.
- Understanding the causes and impact of diarrhoea is crucial for patient management.
Purpose of the Study:
- To investigate the aetiology and clinical features of diarrhoea in renal transplant recipients.
- To compare clinical characteristics between recipients with and without diarrhoea.
- To assess the impact of diarrhoea on patient outcomes, including mortality.
Main Methods:
- Retrospective evaluation of diarrhoea episodes in renal transplant recipients from 1985 to 2000.
- Comparison of clinical features between patients with and without diarrhoea.
- Analysis of aetiology, duration, and outcomes of diarrhoeal episodes.
Main Results:
- Diarrhoea occurred in 12.6% of recipients, with infections (41.5%) and drugs (34%) being the most common causes.
- Diarrhoeal patients exhibited higher creatinine and lower albumin levels, and increased antibiotic usage.
- Diarrhoea contributed to mortality in 5.1% of infection-related deaths, with Clostridium difficile identified in fatal cases.
Conclusions:
- Infections and drugs are primary drivers of diarrhoea in renal transplant recipients.
- Diarrhoea significantly impacts patient health and is an important cause of mortality in this population.