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Related Experiment Videos

Delay and survival in bladder cancer.

D M A Wallace1, R T Bryan, J A Dunn

  • 1Department of Urology, The Queen Elizabeth Hospital, Birmingham, UK. dmwallace@aol.com

BJU International
|May 16, 2002
PubMed
Summary

Prompt diagnosis and treatment are crucial for urothelial cancer survival. Shorter patient delay to general practitioner (GP) referral significantly improves 5-year survival, while hospital delays show complex effects.

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Area of Science:

  • Urology
  • Oncology
  • Public Health

Background:

  • Delays in cancer diagnosis and treatment can negatively impact patient prognosis.
  • Understanding the components of diagnostic and treatment delays is essential for improving cancer care pathways.
  • Urothelial carcinoma, a significant cause of cancer-related mortality, requires timely intervention.

Purpose of the Study:

  • To comprehensively evaluate the impact of diagnostic and treatment delays on urothelial cancer survival.
  • To dissect delays into patient, general practitioner (GP), and hospital components.
  • To identify critical delay periods influencing patient outcomes.

Main Methods:

  • Prospective data collection on 1537 new urothelial cancer cases.
  • Analysis of survival data censored up to 10 years post-diagnosis.

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  • Exploration of the relationship between different delay intervals and patient survival.

    • Main Results:

    • Median delays: 14 days (symptoms to GP), 28 days (GP to hospital), 20 days (hospital to resection).
    • Shorter patient delay (symptoms to GP) correlated with lower tumor stage and improved 5-year survival.
    • Longer hospital delays were associated with worse survival; total delay showed no significant survival effect.

    Conclusions:

    • Referral to hospital within 14 days of symptom onset is linked to significantly better survival.
    • The association between delay and bladder cancer survival is intricate, with hospital delays potentially influenced by comorbidity.
    • Adverse effects of delay are most pronounced in patients with pT1 tumors.