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Efficacy of microfiltration in decreasing propofol-induced pain
A F Davies1, B Vadodaria, B Hopwood
1Department of Anaesthesia, Royal Devon and Exeter Hospital, Exeter UK.
Abstract:
In a randomised, double-blinded, two-centre trial we evaluated the effect of a microbiological filter (Supor, Pall Life Sciences) on propofol injection pain. We studied 336 unpremedicated adult patients, who graded pain experienced during induction of anaesthesia with propofol on a 4-point verbal rating scale. Use of the microfilter reduced both the incidence and severity of propofol injection pain (p < 0.001). Incidence of severe pain in the filter group was 2.4% compared with 16.6% in the control group. Overall, 33.7% in the filter group experienced pain compared with 62.1% in the control group. A microbiological filter may provide a non-pharmacological alternative to a lidocaine/propofol mixture for reducing injection pain. It would also reduce the risk of any glass and bacterial contamination.
Insights
A microbiological filter significantly reduced propofol injection pain in a clinical trial. This non-pharmacological method offers an alternative to reduce pain and contamination risks during anesthesia induction.
Area of Science:
- Anesthesiology
- Medical Devices
- Infection Control
Background:
- Propofol is a common anesthetic agent.
- Injection pain is a frequent side effect of propofol administration.
- Current methods to mitigate pain include pharmacological interventions like lidocaine.
Purpose of the Study:
- To evaluate the efficacy of a microbiological filter in reducing propofol injection pain.
- To compare pain incidence and severity between patients receiving propofol with and without a filter.
Main Methods:
- A randomized, double-blinded, two-center trial was conducted.
- 336 unpremedicated adult patients were studied.
- Pain was assessed using a 4-point verbal rating scale during propofol induction.
Main Results:
- The microbiological filter significantly reduced propofol injection pain (p < 0.001).
- Severe pain incidence was 2.4% with the filter versus 16.6% without.
- Overall pain incidence was 33.7% with the filter compared to 62.1% without.
Conclusions:
- Microbiological filters offer a non-pharmacological approach to decrease propofol injection pain.
- This method may serve as an alternative to lidocaine/propofol mixtures.
- Filters also mitigate risks of glass particulate and bacterial contamination.