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Efficacy of microfiltration in decreasing propofol-induced pain

A F Davies1, B Vadodaria, B Hopwood

  • 1Department of Anaesthesia, Royal Devon and Exeter Hospital, Exeter UK.

Anaesthesia
|May 16, 2002
PubMed

Insights

A microbiological filter significantly reduced propofol injection pain in a clinical trial. This non-pharmacological method offers an alternative to reduce pain and contamination risks during anesthesia induction.

Area of Science:

  • Anesthesiology
  • Medical Devices
  • Infection Control

Background:

  • Propofol is a common anesthetic agent.
  • Injection pain is a frequent side effect of propofol administration.
  • Current methods to mitigate pain include pharmacological interventions like lidocaine.

Purpose of the Study:

  • To evaluate the efficacy of a microbiological filter in reducing propofol injection pain.
  • To compare pain incidence and severity between patients receiving propofol with and without a filter.

Main Methods:

  • A randomized, double-blinded, two-center trial was conducted.
  • 336 unpremedicated adult patients were studied.
  • Pain was assessed using a 4-point verbal rating scale during propofol induction.

Main Results:

  • The microbiological filter significantly reduced propofol injection pain (p < 0.001).
  • Severe pain incidence was 2.4% with the filter versus 16.6% without.
  • Overall pain incidence was 33.7% with the filter compared to 62.1% without.

Conclusions:

  • Microbiological filters offer a non-pharmacological approach to decrease propofol injection pain.
  • This method may serve as an alternative to lidocaine/propofol mixtures.
  • Filters also mitigate risks of glass particulate and bacterial contamination.

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