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A new liquid embolic material for liver tumors
A Komemushi1, N Tanigawa, Y Okuda
1Department of Radiology, Kansai Medical University, Osaka, Japan.
Acta Radiologica (Stockholm, Sweden : 1987)
|May 16, 2002
Summary
This study found that Onyx, a new liquid embolic material, is feasible for treating liver tumors by embolizing hepatic arteries. Different Onyx concentrations effectively reached various arterial branching points and diameters in rabbit liver models.
Area of Science:
- Interventional Radiology
- Vascular Embolization
- Oncology
Background:
- Liver tumors pose a significant challenge in oncological treatment.
- Transarterial embolization is a common therapeutic approach for liver malignancies.
- Novel embolic agents are continuously being investigated to improve treatment efficacy and safety.
Purpose of the Study:
- To assess the feasibility of Onyx, a novel liquid embolic material, for the treatment of hepatic tumors.
- To evaluate the penetration and distribution characteristics of Onyx in rabbit liver vasculature.
Main Methods:
- Onyx, a copolymer dissolved in dimethyl sulfoxide (DMSO) with tantalum powder, was tested in 1% to 6% concentrations.
- Liver tumors were induced in 15 white rabbits via VX2 tumor cell injection.
- Hepatic arteries were embolized with varying Onyx concentrations, followed by arteriography and post-mortem examination.
Main Results:
- Onyx demonstrated progressive penetration into arterial branching points with decreasing concentrations (up to 16 branches for 2% Onyx).
- The material reached progressively smaller arterial diameters (down to 10 micrometers in tumorous areas and 5 micrometers in non-tumorous areas) with lower concentrations.
- DMSO alone served as a control, with no embolic effect observed.
Conclusions:
- Onyx exhibits promising feasibility as an embolic agent for liver tumor treatment.
- The study supports further investigation into Onyx for clinical application in hepatic tumor embolization.